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Home - Products - Cell Cycle/DNA Damage - Rho - CCG-222740

CCG-222740

CAS No. 1922098-69-8

CCG-222740( —— )

Catalog No. M21055 CAS No. 1922098-69-8

CCG-222740 is an inhibitor of Rho/MRTF pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 53 Get Quote
5MG 88 Get Quote
10MG 152 Get Quote
25MG 286 Get Quote
50MG 441 Get Quote
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Biological Information

  • Product Name
    CCG-222740
  • Note
    Research use only, not for human use.
  • Brief Description
    CCG-222740 is an inhibitor of Rho/MRTF pathway.
  • Description
    CCG-222740 is an inhibitor of Rho/MRTF pathway.
  • In Vitro
    Cell Cycle Analysis Cell Line:Cancer associated fibroblasts (CAFs) Concentration:10, 20 μM Incubation Time:72 hours Result:Increased the protein levels of p27 and decreased cyclin D1.
  • In Vivo
    Animal Model:KC mice (LSL-KrasG12D/+; Pdx-1-Cre) of age at 9 weeks Dosage:100?mg/kg Administration:Oral gavage; daily; for 7 days Result:Reduced α-SMA levels in the pancreas of caerulein-stimulated KC mice.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Rho
  • Recptor
    Rho
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1922098-69-8
  • Formula Weight
    444.86
  • Molecular Formula
    C23H19ClF2N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(280.99 Mm)
  • SMILES
    O=C(Nc1ccc(Cl)cc1)C1CN(C(=O)c2cccc(-c3ccco3)c2)CC(F)(F)C1
  • Chemical Name
    N-(4-chlorophenyl)-55-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yu-Wai-Man C Spencer-Dene B Lee R M H et al. Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis[J]. Scientific Reports 2017 7(1):518.
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