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CCG-222740
CAS No. 1922098-69-8
CCG-222740( —— )
Catalog No. M21055 CAS No. 1922098-69-8
CCG-222740 is an inhibitor of Rho/MRTF pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 61 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 56 | In Stock |
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| 10MG | 96 | In Stock |
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| 25MG | 181 | In Stock |
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| 50MG | 269 | In Stock |
|
| 100MG | 384 | In Stock |
|
| 200MG | 548 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCCG-222740
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NoteResearch use only, not for human use.
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Brief DescriptionCCG-222740 is an inhibitor of Rho/MRTF pathway.
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DescriptionCCG-222740 is an inhibitor of Rho/MRTF pathway.
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In VitroCell Cycle Analysis Cell Line:Cancer associated fibroblasts (CAFs) Concentration:10, 20 μM Incubation Time:72 hours Result:Increased the protein levels of p27 and decreased cyclin D1.
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In VivoAnimal Model:KC mice (LSL-KrasG12D/+; Pdx-1-Cre) of age at 9 weeks Dosage:100?mg/kg Administration:Oral gavage; daily; for 7 days Result:Reduced α-SMA levels in the pancreas of caerulein-stimulated KC mice.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetRho
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RecptorRho
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Research Area——
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Indication——
Chemical Information
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CAS Number1922098-69-8
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Formula Weight444.86
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Molecular FormulaC23H19ClF2N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL?(280.99 Mm)
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SMILESO=C(Nc1ccc(Cl)cc1)C1CN(C(=O)c2cccc(-c3ccco3)c2)CC(F)(F)C1
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Chemical NameN-(4-chlorophenyl)-55-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yu-Wai-Man C Spencer-Dene B Lee R M H et al. Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis[J]. Scientific Reports 2017 7(1):518.
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