Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - Rho - CCG-222740

CCG-222740

CAS No. 1922098-69-8

CCG-222740( —— )

Catalog No. M21055 CAS No. 1922098-69-8

CCG-222740 is an inhibitor of Rho/MRTF pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 61 In Stock
2MG 33 In Stock
5MG 56 In Stock
10MG 96 In Stock
25MG 181 In Stock
50MG 269 In Stock
100MG 384 In Stock
200MG 548 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    CCG-222740
  • Note
    Research use only, not for human use.
  • Brief Description
    CCG-222740 is an inhibitor of Rho/MRTF pathway.
  • Description
    CCG-222740 is an inhibitor of Rho/MRTF pathway.
  • In Vitro
    Cell Cycle Analysis Cell Line:Cancer associated fibroblasts (CAFs) Concentration:10, 20 μM Incubation Time:72 hours Result:Increased the protein levels of p27 and decreased cyclin D1.
  • In Vivo
    Animal Model:KC mice (LSL-KrasG12D/+; Pdx-1-Cre) of age at 9 weeks Dosage:100?mg/kg Administration:Oral gavage; daily; for 7 days Result:Reduced α-SMA levels in the pancreas of caerulein-stimulated KC mice.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Rho
  • Recptor
    Rho
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1922098-69-8
  • Formula Weight
    444.86
  • Molecular Formula
    C23H19ClF2N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(280.99 Mm)
  • SMILES
    O=C(Nc1ccc(Cl)cc1)C1CN(C(=O)c2cccc(-c3ccco3)c2)CC(F)(F)C1
  • Chemical Name
    N-(4-chlorophenyl)-55-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yu-Wai-Man C Spencer-Dene B Lee R M H et al. Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis[J]. Scientific Reports 2017 7(1):518.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • ITX3

    ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.

  • CCG-257081

    CCG-257081 (MRTF/SRF-IN-1) is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.CCG-257081 has shown efficacy in preventing bleomycin-induced fibrosis in several mouse models.

  • SAR407899

    SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.

Sign In Join Free