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NS1643

CAS No. 448895-37-2

NS1643( NS-1643 | NS 1643 | NS1643 )

Catalog No. M18560 CAS No. 448895-37-2

NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 90 In Stock
50MG 164 In Stock
100MG 281 In Stock
200MG 365 In Stock
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Biological Information

  • Product Name
    NS1643
  • Note
    Research use only, not for human use.
  • Brief Description
    NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.
  • Description
    NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). NS1643 increased both steady-state and tail current at all voltages tested. The EC(50) value for HERG channel activation was 10.5 microM. HERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents an interesting new antiarrhythmic approach.
  • In Vitro
    Western Blot Analysis Cell Line:MDA-MB-231, SKBR3 and MCF7 breast cancer cell lines Concentration:50 μM Incubation Time:24 h Result:Decreased Vimentin, N-cadherin and CD44 levels, and increased E-cadherin in breast cancer cell lines.
  • In Vivo
    Animal Model:NSG mice with human-derived TNBC tumor xenografts Dosage:6 mg/kg Administration:Intraperitoneal injection; 6 mg/kg; twice per week Result:Significantly reduceed tumor .growth and the metastatic liver tumors were significantly smaller than those in the control group. Decreased levels of human nuclear antigen (HNA).
  • Synonyms
    NS-1643 | NS 1643 | NS1643
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Rho
  • Recptor
    hERG
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    448895-37-2
  • Formula Weight
    380.24
  • Molecular Formula
    C15H10F6N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL; 262.99 mM
  • SMILES
    c1c(ccc(c1NC(=O)Nc1c(O)ccc(c1)C(F)(F)F)O)C(F)(F)F
  • Chemical Name
    1,3-bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Casis O, et al. Mol Pharmacol. 2006 Feb;69(2):658-65.
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