NS1643( NS-1643 | NS 1643 | NS1643 )

Catalog No. M18560 CAS No. 448895-37-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

NS1643
Note

Research use only, not for human use.
Brief Description

NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.
Description

NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). NS1643 increased both steady-state and tail current at all voltages tested. The EC(50) value for HERG channel activation was 10.5 microM. HERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents an interesting new antiarrhythmic approach.
In Vitro

Western Blot Analysis Cell Line:MDA-MB-231, SKBR3 and MCF7 breast cancer cell lines Concentration:50 μM Incubation Time:24 h Result:Decreased Vimentin, N-cadherin and CD44 levels, and increased E-cadherin in breast cancer cell lines.
In Vivo

Animal Model:NSG mice with human-derived TNBC tumor xenografts Dosage:6 mg/kg Administration:Intraperitoneal injection; 6 mg/kg; twice per week Result:Significantly reduceed tumor .growth and the metastatic liver tumors were significantly smaller than those in the control group. Decreased levels of human nuclear antigen (HNA).
Synonyms

NS-1643 | NS 1643 | NS1643
Pathway

Cell Cycle/DNA Damage
Target

Rho
Recptor

hERG
Research Area

Others-Field
Indication

——

1. Casis O, et al. Mol Pharmacol. 2006 Feb;69(2):658-65.

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