CCG-1423

Research use only, not for human use.

CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.

CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.

Cell Invasion Assay Cell Line:PC-3 cell line Concentration:10 μM Incubation Time:24 hours Result:Inhibited 71% invasion by cultured PC-3 cells into a Matrigel matrix.Western Blot Analysis Cell Line:L6 myotubes Concentration:1 μM Incubation Time:48 hours Result:Increased insulin-stimulated Akt phosphorylation, blocked ERK phosphorylation, and increased IRS-1 tyrosine phosphorylation and its association with the p85 regulatory subunit of PI3K.Cell Proliferation Assay Cell Line:PC-3 cell lineConcentration:0.3 μM Incubation Time:8 days Result:Inhibited growth of PC-3 prostate cancer cells with an IC50 value of 1 μM with 30 μM LPA adding.Apoptosis Analysis Cell Line:RhoC-overexpressing A375M2 and low RhoC-expressing A375 melanoma cell lines Concentration:3 μM Incubation Time:25 hours Result:Stimulated apoptosis of A375M2 cell line compared with the parental cell line.

Animal Model:16-week-old mice with HFD-induced obesity Dosage:0.15 mg/kg Administration:Intraperitoneal injection; 0.15 mg/kg once per day; for two weeks Result:Improved glucose tolerance and reduced insulin levels at 30 minutes after glucose injection.

CCG1423 | CCG-1423 | CCG 1423

Cell Cycle/DNA Damage

Rho

RhoA

Cancer

——

285986-88-1

454.75

C18H13ClF6N2O3

>98% (HPLC)

Ethanol: 4 mg/mL warmed (8.79 mM); DMSO: 90 mg/mL (197.91 mM)

O=C(NOC(C)C(NC1=CC=C(Cl)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years