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Home - Products - Cell Cycle/DNA Damage - Rho - CCG-257081

CCG-257081

CAS No. 1922098-90-5

CCG-257081( —— )

Catalog No. M34540 CAS No. 1922098-90-5

CCG-257081 (MRTF/SRF-IN-1) is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.CCG-257081 has shown efficacy in preventing bleomycin-induced fibrosis in several mouse models.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CCG-257081
  • Note
    Research use only, not for human use.
  • Brief Description
    CCG-257081 (MRTF/SRF-IN-1) is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.CCG-257081 has shown efficacy in preventing bleomycin-induced fibrosis in several mouse models.
  • Description
    MRTF/SRF-IN-1 (example 41) is an inhibitor of both myocardin-related transcription factor and serum response factor (MRTF/SRF). MRTF/SRF-IN-1 can be used for research for preventing cancer and fibrosis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Rho
  • Recptor
    Rho | Ras
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1922098-90-5
  • Formula Weight
    473.87
  • Molecular Formula
    C24H19ClF3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (211.03 mM; Ultrasonic )
  • SMILES
    C(=O)(C=1C=C(C=C(F)C1)C=2C=CN=CC2)N3CC(C(NC4=CC=C(Cl)C=C4)=O)CC(F)(F)C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Larsen Scott D, et al. Preparation of substituted piperidine-3-carboxamides as inhibitors of myocardin-related transcription factor and serum response factor (MTRF/SRF)-mediated gene transcription. World Intellectual Property Organization, WO2016073847 A2. 2016-05-12.
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