Cart
sales@molnova.com
SJB2-043
CAS No. 63388-44-3
SJB2-043( —— )
Catalog No. M20973 CAS No. 63388-44-3
SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 49 | In Stock |
|
| 5MG | 45 | In Stock |
|
| 10MG | 76 | In Stock |
|
| 25MG | 169 | In Stock |
|
| 50MG | 269 | In Stock |
|
| 100MG | 423 | In Stock |
|
| 200MG | 611 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSJB2-043
-
NoteResearch use only, not for human use.
-
Brief DescriptionSJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
-
DescriptionSJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
-
In VitroSJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC50 of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner.
-
In Vivo——
-
Synonyms——
-
PathwayProteasome/Ubiquitin
-
TargetDUB
-
RecptorUSP1-UAF1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number63388-44-3
-
Formula Weight275.26
-
Molecular FormulaC17H9NO3
-
Purity>98% (HPLC)
-
SolubilityDMSO:3.33 mg/mL (12.10 mM)
-
SMILESO=C1c2ccccc2C(=O)c2oc(-c3ccccc3)nc21
-
Chemical Name2-Phenyl-naphth[23-d]oxazole-49-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Jussara Maria Goncalves et al. The Role of the Complex USP1/WDR48 in Differentiation and Proliferation Processes in Cancer Stem Cells.[J]. Current stem cell research & therapy 2017.
molnova catalog
related products
-
C527
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
-
Wu-5
Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.
-
BRD 0476
BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X).
