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Phenprocoumon

CAS No. 435-97-2

Phenprocoumon( —— )

Catalog No. M20960 CAS No. 435-97-2

Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Phenprocoumon
  • Note
    Research use only, not for human use.
  • Brief Description
    Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).
  • Description
    Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).(In Vivo):After a single i.v.-dose of phenprocoumon (0.355 mg/kg) the anticoagulant effect obtained is greater in older than in younger rats. There are no differences between younger and older rats in the rate of elimination, volume of distribution and in the free fraction and free concentration values of phenprocoumon in plasma and liver. After i.v.-injection of 64.3 μg/kg [3H]vitamin K1 and different doses of phenprocoumon (0.02 to 3 mg/kg) the [3H]vitamin K1 concentration in the liver decreases and the [3H] vitamin K1-2, 3-epoxide concentration increases dependent on the dose and the liver concentration of phenprocoumon. These changes are more pronounced in the older than in the younger rats.
  • In Vitro
    ——
  • In Vivo
    After a single i.v.-dose of phenprocoumon (0.355 mg/kg) the anticoagulant effect obtained is greater in older than in younger rats. There are no differences between younger and older rats in the rate of elimination, volume of distribution and in the free fraction and free concentration values of phenprocoumon in plasma and liver. After i.v.-injection of 64.3 μg/kg [3H]vitamin K1 and different doses of phenprocoumon (0.02 to 3 mg/kg) the [3H]vitamin K1 concentration in the liver decreases and the [3H] vitamin K1-2, 3-epoxide concentration increases dependent on the dose and the liver concentration of phenprocoumon. These changes are more pronounced in the older than in the younger rats.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Vitamin
  • Recptor
    vitamin K
  • Research Area
    Cardiovascular Disease
  • Indication
    thromboembolic disease

Chemical Information

  • CAS Number
    435-97-2
  • Formula Weight
    280.32
  • Molecular Formula
    C18H16O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (445.92 mM)
  • SMILES
    CCC(c1ccccc1)c1c(O)c2ccccc2oc1=O
  • Chemical Name
    4-hydroxy-3-(1-phenylpropyl)chromen-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Martin Müller Fabian et al. Characteristics treatment and outcome of bleeding after tooth extraction in patients on DOAC and phenprocoumon compared to non-anticoagulated patients-a retrospective study of emergency department consultations.[J]. Clinical oral investigations 2018.
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