Phenprocoumon

Research use only, not for human use.

Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).

Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).(In Vivo):After a single i.v.-dose of phenprocoumon (0.355 mg/kg) the anticoagulant effect obtained is greater in older than in younger rats. There are no differences between younger and older rats in the rate of elimination, volume of distribution and in the free fraction and free concentration values of phenprocoumon in plasma and liver. After i.v.-injection of 64.3 μg/kg [3H]vitamin K1 and different doses of phenprocoumon (0.02 to 3 mg/kg) the [3H]vitamin K1 concentration in the liver decreases and the [3H] vitamin K1-2, 3-epoxide concentration increases dependent on the dose and the liver concentration of phenprocoumon. These changes are more pronounced in the older than in the younger rats.

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After a single i.v.-dose of phenprocoumon (0.355 mg/kg) the anticoagulant effect obtained is greater in older than in younger rats. There are no differences between younger and older rats in the rate of elimination, volume of distribution and in the free fraction and free concentration values of phenprocoumon in plasma and liver. After i.v.-injection of 64.3 μg/kg [3H]vitamin K1 and different doses of phenprocoumon (0.02 to 3 mg/kg) the [3H]vitamin K1 concentration in the liver decreases and the [3H] vitamin K1-2, 3-epoxide concentration increases dependent on the dose and the liver concentration of phenprocoumon. These changes are more pronounced in the older than in the younger rats.

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Metabolic Enzyme/Protease

Vitamin

vitamin K

Cardiovascular Disease

thromboembolic disease

435-97-2

280.32

C18H16O3

>98% (HPLC)

DMSO:125 mg/mL (445.92 mM)

CCC(c1ccccc1)c1c(O)c2ccccc2oc1=O

4-hydroxy-3-(1-phenylpropyl)chromen-2-one

(-20℃)

With Ice Pack

≥ 2 years