BAY-598( —— )

Catalog No. M20776 CAS No. 1906919-67-2

BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	93	In Stock
5MG	84	In Stock
10MG	135	In Stock
25MG	250	In Stock
50MG	398	In Stock
100MG	600	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

BAY-598
Note

Research use only, not for human use.
Brief Description

BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
Description

BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
In Vitro

BAY-598 treatment blocks in vitro methylation of MAPKAPK3 by SMYD2 but has no activity against the SMYD2-related KMT SMYD3. BAY-598 treatment reduces the growth of Kras;p53 mutant PDAC cells after 9 d in culture but has little impact on the growth of Kras;p53;Smyd2 mutant cells.
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

SMYD2
Research Area

——
Indication

——

Chemical Information

CAS Number

1906919-67-2
Formula Weight

525.34
Molecular Formula

C22H20Cl2F2N6O3
Purity

>98% (HPLC)
Solubility

DMSO:125 mg/mL (237.94 mM)
SMILES

CCN(C(=O)CO)C1CN(C(=Nc2cccc(OC(F)F)c2)NC#N)N=C1c1ccc(Cl)c(Cl)c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Reynoird N Mazur P K Stellfeld T et al. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer[J]. Genes & Development 2016:genesdev;gad.275529.115v1.

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