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DDP-38003 dihydrochloride
CAS No. 1831167-98-6
DDP-38003 dihydrochloride( DDP 38003 dihydrochloride | DDP38003 dihydrochloride )
Catalog No. M12821 CAS No. 1831167-98-6
DDP-38003 is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with IC50 of 84 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 161 | In Stock |
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| 5MG | 133 | In Stock |
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| 10MG | 228 | In Stock |
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| 25MG | 508 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDDP-38003 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionDDP-38003 is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with IC50 of 84 nM.
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DescriptionDDP-38003 is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with IC50 of 84 nM; weakly inhibits MAO-A and has no activity for KDM1B and MAO-B (IC50>30 uM); orally bioactive and exhibits in vivo efficacy in mouse leukemia model.Blood Cancer Preclinical.
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In VitroDDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue.
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In VivoDDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent.
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SynonymsDDP 38003 dihydrochloride | DDP38003 dihydrochloride
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorHistone Demethylase
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1831167-98-6
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Formula Weight423.37922
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Molecular FormulaC21H28Cl2N4O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 29 mg/mL
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SMILESCN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C4CC4N.Cl.Cl
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Chemical NameBenzamide, N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methyl-1-piperazinyl)-, hydrochloride (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vianello P, et al. J Med Chem. 2016 Feb 25;59(4):1501-17.
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