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SSE15206
CAS No. 1370046-40-4
SSE15206( —— )
Catalog No. M20392 CAS No. 1370046-40-4
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 37 | In Stock |
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| 5MG | 54 | In Stock |
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| 10MG | 70 | In Stock |
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| 25MG | 141 | In Stock |
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| 50MG | 217 | In Stock |
|
| 100MG | 339 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSSE15206
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NoteResearch use only, not for human use.
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Brief DescriptionSSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
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DescriptionSSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
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In VitroSSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines. Western Blot Analysis Cell Line:Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells. Concentration:5 × and 10 × GI50 values (GI50=197 nM in HCT-116 cells).Incubation Time:24 hours.Result:Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells.
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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Recptormicrotubule
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Research Area——
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Indication——
Chemical Information
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CAS Number1370046-40-4
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Formula Weight371.45
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Molecular FormulaC19H21N3O3S?
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Purity>98% (HPLC)
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SolubilityDMSO:150 mg/mL (403.82 mM)
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SMILESCOc1cc(cc(OC)c1OC)C1CC(=NN1C(N)=S)c1ccccc1
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Chemical Name45-Dihydro-3-phenyl-5-(345-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Manzoor S Bilal A Khan S et al. Identification and characterization of SSE15206 a microtubule depolymerizing agent that overcomes multidrug resistance[J]. Scientific Reports 2018 8(1).
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