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SSE15206

CAS No. 1370046-40-4

SSE15206( —— )

Catalog No. M20392 CAS No. 1370046-40-4

SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
10MG 29 In Stock
25MG 50 In Stock
50MG 82 In Stock
100MG 127 In Stock
200MG 183 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    SSE15206
  • Note
    Research use only, not for human use.
  • Brief Description
    SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
  • Description
    SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
  • In Vitro
    SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines. Western Blot Analysis Cell Line:Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells. Concentration:5 × and 10 × GI50 values (GI50=197 nM in HCT-116 cells).Incubation Time:24 hours.Result:Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Microtubule/Tubulin
  • Recptor
    microtubule
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1370046-40-4
  • Formula Weight
    371.45
  • Molecular Formula
    C19H21N3O3S?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (403.82 mM)
  • SMILES
    COc1cc(cc(OC)c1OC)C1CC(=NN1C(N)=S)c1ccccc1
  • Chemical Name
    45-Dihydro-3-phenyl-5-(345-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Manzoor S Bilal A Khan S et al. Identification and characterization of SSE15206 a microtubule depolymerizing agent that overcomes multidrug resistance[J]. Scientific Reports 2018 8(1).
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