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McMMAF
CAS No. 863971-19-1
McMMAF( Maleimidocaproyl monomethylauristatin F )
Catalog No. M24863 CAS No. 863971-19-1
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 116 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 432 | In Stock |
|
| 50MG | 592 | In Stock |
|
| 100MG | 770 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMcMMAF
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NoteResearch use only, not for human use.
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Brief DescriptionMcMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.
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DescriptionMcMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other proteins or biopolymers. Mafodotin is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery.
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In Vitro——
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In Vivo——
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SynonymsMaleimidocaproyl monomethylauristatin F
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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Recptortubulin polymerization|Drug-Linker Conjugates for ADC
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Research Area——
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Indication——
Chemical Information
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CAS Number863971-19-1
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Formula Weight925.16
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Molecular FormulaC49H76N6O11
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (108.09 mM)
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SMILESO=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@H]2N(C(C[C@@H](OC)[C@@H](N(C)C([C@@H](NC([C@@H](N(C)C(CCCCCN3C(C=CC3=O)=O)=O)C(C)C)=O)C(C)C)=O)[C@@H](C)CC)=O)CCC2)OC)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009 Mar 15;69(6):2358-2364.
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