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Briciclib
CAS No. 865783-99-9
Briciclib( ON 014185 )
Catalog No. M19193 CAS No. 865783-99-9
Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 47 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 115 | In Stock |
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| 25MG | 237 | In Stock |
|
| 50MG | 356 | In Stock |
|
| 100MG | 530 | In Stock |
|
| 500MG | 1152 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBriciclib
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NoteResearch use only, not for human use.
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Brief DescriptionBriciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.
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DescriptionBriciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.(In Vitro):Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.
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In VitroBriciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.
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In Vivo——
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SynonymsON 014185
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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RecptorCyclin D1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number865783-99-9
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Formula Weight474.42
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Molecular FormulaC19H23O10PS
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 31 mg/mL; 65.34 mM
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SMILESc1(cc(c(c(c1)OC)/C=C/S(=O)(=O)Cc1ccc(c(c1)OP(=O)(O)O)OC)OC)OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Neel Jasani, et al. DOI: 10.1158/1538-7445.
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