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Demecolcine

CAS No. 477-30-5

Demecolcine( Colcemid | C-12669 | C 12669 | C12669 | Kolchicin | NSC-3096 )

Catalog No. M24425 CAS No. 477-30-5

Demecolcine is an inhibitor of microtubule polymerization. It used to study embryonic cloning.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Demecolcine
  • Note
    Research use only, not for human use.
  • Brief Description
    Demecolcine is an inhibitor of microtubule polymerization. It used to study embryonic cloning.
  • Description
    Demecolcine is an inhibitor of microtubule polymerization. It used to study embryonic cloning.
  • In Vitro
    ——
  • In Vivo
    Animal Model:MiceDosage:0.3 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Elevated 7.8-8-fold of the hypoploid and hyperploid frequencies in metaphase II cells relative to controls.
  • Synonyms
    Colcemid | C-12669 | C 12669 | C12669 | Kolchicin | NSC-3096
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Microtubule/Tubulin
  • Recptor
    Microtubule/Tubulin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    477-30-5
  • Formula Weight
    371.43
  • Molecular Formula
    C21H25NO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (67.31 mM)
  • SMILES
    O=C1C=C2[C@@H](NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=CC=C1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gao Y, Ren J, Zhang L, Zhang Y, Wu X, Jiang H, Xu F, Yuan B, Yu X, Zhang J. The effects of demecolcine, alone or in combination with sucrose on bovine oocyte protrusion rate, MAPK1 protein level and c-mos gene expression level. Cell Physiol Biochem. 2014;34(6):1974-82. doi: 10.1159/000366393. Epub 2014 Nov 25.
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