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Cycloguanil hydrochloride

CAS No. 152-53-4

Cycloguanil hydrochloride( Chloroguanide Triazine )

Catalog No. M20150 CAS No. 152-53-4

Cycloguanil is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 33 In Stock
5MG 29 In Stock
10MG 43 In Stock
25MG 70 In Stock
50MG 99 In Stock
100MG 145 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Cycloguanil hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Cycloguanil is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms respectively).
  • Description
    Cycloguanil is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms respectively).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Chloroguanide Triazine
  • Pathway
    Microbiology/Virology
  • Target
    Parasite
  • Recptor
    Parasite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    152-53-4
  • Formula Weight
    288.18
  • Molecular Formula
    C11H14ClN5.ClH
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 20 mg/mL (69.4 mM);Water: 5 mg/mL (17.35 mM)
  • SMILES
    Cl.CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wright JD et al. The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. Br J Clin Pharmacol. 1995 Apr;39(4):441-4.
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