Cart
sales@molnova.com
Home - Products - Angiogenesis - Bcl-2 - ML311

ML311

CAS No. 315698-17-0

ML311( —— )

Catalog No. M19904 CAS No. 315698-17-0

ML311 is a selective inhibitor of the Mcl-1/Bim interaction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 85 In Stock
5MG 76 In Stock
10MG 122 In Stock
25MG 239 In Stock
50MG 367 In Stock
100MG 553 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    ML311
  • Note
    Research use only, not for human use.
  • Brief Description
    ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
  • Description
    ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
  • In Vitro
    ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Mcl-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    315698-17-0
  • Formula Weight
    415.45
  • Molecular Formula
    C23H24F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 20 mg/mL;Water: Insoluble;Ethanol: 20 mg/mL
  • SMILES
    CCN1CCN(CC1)C(c1ccc(cc1)C(F)(F)F)c1ccc2cccnc2c1O
  • Chemical Name
    7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bannister T et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Biotechnology Information (US); 2010-2012 Apr 16.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Apogossypol

    Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.

  • BCL6-IN-8

    BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface.

  • BM-957

    BM-957 is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively.

Sign In Join Free