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ML311
CAS No. 315698-17-0
ML311( —— )
Catalog No. M19904 CAS No. 315698-17-0
ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 122 | In Stock |
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| 25MG | 239 | In Stock |
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| 50MG | 367 | In Stock |
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| 100MG | 553 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML311
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NoteResearch use only, not for human use.
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Brief DescriptionML311 is a selective inhibitor of the Mcl-1/Bim interaction.
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DescriptionML311 is a selective inhibitor of the Mcl-1/Bim interaction.
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In VitroML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetBcl-2
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RecptorMcl-1
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Research Area——
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Indication——
Chemical Information
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CAS Number315698-17-0
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Formula Weight415.45
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Molecular FormulaC23H24F3N3O
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Purity>98% (HPLC)
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SolubilityDMSO: 20 mg/mL;Water: Insoluble;Ethanol: 20 mg/mL
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SMILESCCN1CCN(CC1)C(c1ccc(cc1)C(F)(F)F)c1ccc2cccnc2c1O
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Chemical Name7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bannister T et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Biotechnology Information (US); 2010-2012 Apr 16.
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