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Cilengitide trifluoroacetate
CAS No. 199807-35-7
Cilengitide trifluoroacetate( EMD 121974 | NSC 707544 )
Catalog No. M19460 CAS No. 199807-35-7
Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCilengitide trifluoroacetate
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NoteResearch use only, not for human use.
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Brief DescriptionCilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
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DescriptionCilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
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In Vitro——
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In Vivo——
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SynonymsEMD 121974 | NSC 707544
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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Recptorαvβ3 receptor |αvβ5 receptor
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Research AreaCancer
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IndicationGlioblastoma; Head and neck Cancer; Lymphoma; Non-small cell lung Cancer; Prostate Cancer; Solid tumours
Chemical Information
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CAS Number199807-35-7
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Formula Weight702.68
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Molecular FormulaC29H41F3N8O9
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Purity>98% (HPLC)
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SolubilityDMSO:93 mg/mL (132.4 mM);Ethanol:<1 mg/mL;Water:8 mg/mL (11.38 mM)
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SMILESOC(=O)C(F)(F)F.CC(C)[C@@H]1N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Fibronectin CS1 Pept...
he connecting segment 1 (CS-1) is a cell attachment domain located in the type III homology connecting segment (IIICS) of fibronectin. CS1 peptide of fibronectin, which lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models. The use of Fibronectin CS1 Peptide might offer a promising therapeutic approach for combating and preventing cancer metastasis.
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Bexotegrast
Bexotegrast (PLN-74809) is an orally active and potent inhibitor of αvβ6 and αvβ1 integrins with antifibrotic effects, inhibiting αvβ6 and αvβ1-induced activation of TGF-β.
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RGDS peptide
RGDS peptide (Arg-Gly-Asp-Ser) is a integrin binding sequence that inhibits integrin receptor function, a tetrapeptide analogue of the cell attachment site of fibronectin.
