Danshensu( Dan shen suan A | Salvianic acid A )

Catalog No. M19093 CAS No. 76822-21-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Danshensu
Note

Research use only, not for human use.
Brief Description

Danshensu is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.
Description

Danshensu is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.
In Vitro

Cell Migration Assay Cell Line:FaDu and Ca9-22 cells Concentration:25, 50, and 100 μM Incubation Time:24 h Result:At higher concentrations (50 and 100 μM) caused significant reduction in migration and invasion of both FaDu and Ca9-22 cells.Western Blot Analysis Cell Line:FaDu and Ca9-22 cells Concentration:25, 50, and 100 μM Incubation Time:24 h Result:Phosphorylation of ERK reduced dose-dependently after 24 h in FaDu cell. Caused significant reduction in p38 phosphorylation.
In Vivo

Animal Model:Adult BALB/c mice (male, 6-8 weeks, 20±2?g)Dosage:25, 50, 100?mg/kg Administration:Oral administration (daily for 7 continuous days) or i.v. (once) Result:Could prevent SARS-CoV-2 S protein-induced acute lung inflammation. Ameliorated inflammatory cytokines in serum and lung tissue.
Synonyms

Dan shen suan A | Salvianic acid A
Pathway

Apoptosis
Target

TNF
Recptor

Others
Research Area

Cardiovascular Disease
Indication

——

1. YG Cao, et al.Br J Pharmacol. 2009 Jun; 157(3): 482–490.

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