Curcumol( Curcumol )

Catalog No. M18633 CAS No. 4871-97-0

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Product Name

Curcumol
Note

Research use only, not for human use.
Brief Description

Curcumol, a pure monomer isolated extracted from Rhizoma Curcumaeis, has antitumor activities.
Description

Curcumol, isolated from the traditional medical plant Rhizoma Curcumae, is the bioactive component of Zedoary oil, whose potential anti-tumor effect has attracted considerable attention in recent years. Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1. Curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer MDA-MB 231 cells via activation of p73 and PUMA. Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats.
In Vitro

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In Vivo

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Synonyms

Curcumol
Pathway

Wnt/Notch/Hedgehog
Target

Wnt/beta/catenin
Recptor

JAK
Research Area

Cancer
Indication

——

CAS Number

4871-97-0
Formula Weight

236.35
Molecular Formula

C15H24O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 423.10 mM; H2O : < 0.1 mg/mL
SMILES

C1C[C@@H]([C@@]23C[C@H]([C@@](CC(=C)[C@H]12)(O3)O)C(C)C)C
Chemical Name

(3S,3aS,5S,6R,8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol

1. Zhang W, et al. Med Oncol, 2011, 28(1), 307-314.

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