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CAY10602
CAS No. 374922-43-7
CAY10602( CAY10602 | CAY-10602 | CAY 10602 )
Catalog No. M18489 CAS No. 374922-43-7
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 38 | In Stock |
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| 25MG | 83 | In Stock |
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| 50MG | 152 | In Stock |
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| 100MG | 259 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCAY10602
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NoteResearch use only, not for human use.
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Brief DescriptionCAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.
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DescriptionCAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
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In VitroCompounds (including CAY10602/compound 1) with SIRT1-activating properties have a significant effect on fat mobilization in differentiated adipocytes, and these compounds (including CAY10602) have antiobesity and/or antidiabetic properties. Compounds (including CAY10602) with SIRT1 activating potential exert strong suppression of TNF-α release at concentrations between 20 and 60 μM.
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In Vivo——
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SynonymsCAY10602 | CAY-10602 | CAY 10602
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PathwayOthers
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TargetOther Targets
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RecptorSIRT1
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Research Area——
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Indication——
Chemical Information
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CAS Number374922-43-7
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Formula Weight418.44
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Molecular FormulaC22H15FN4O2S
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL 238.98 mM
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SMILESFc1ccc(cc1)n1c2nc3ccccc3nc2c(c1N)S(=O)(=O)c1ccccc1
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Chemical Name1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. H?ppner S, et al. Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):35-50.
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