Methylproamine

Research use only, not for human use.

Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA.

Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA.(In Vitro):Immunocytochemical methods were used to measure the accumulation of phosphorylated H2AX (γH2AX) foci following ionizing radiation (IR) in patient-derived lymphoblastoid cells exposed to methylproamine. Pulsed field gel electrophoresis DNA damage and repair assays were performed to directly interrogate the action of methylproamine on DNA in irradiated cells.Methylproamine-treated cells had fewer γH2AX foci after IR compared to untreated cells. Also, the presence of methylproamine decreased the amount of lower molecular weight DNA entering the gel.

Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks.Methylproamine can protect bystander cells from radiation-induced DNA damage.Methylproamine has aconcentration-dependent radioprotective effect.Cell Cytotoxicity Assay Cell Line:Keratinocytes Concentration:10, 20 μMIncubation Time:60 min Result:Did not show any detectable cytotoxicity at 10 μM and had appreciable cytotoxicity at 20 μM.

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Others

Other Targets

α2 adrenergic receptor

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188247-01-0

465.605

C28H31N7

>98% (HPLC)

In Vitro:?DMSO : ≥ 41 mg/mL (88.06 mM)

CN(C)c1ccc(-c2nc3ccc(cc3[nH]2)-c2nc3ccc(cc3[nH]2)N2CCN(C)CC2)c(C)c1

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(-20℃)

With Ice Pack

≥ 2 years