Fraxinellone( Fraxinellone )

Catalog No. M18367 CAS No. 28808-62-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Fraxinellone
Note

Research use only, not for human use.
Brief Description

Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease.
Description

Fraxinellone has anti-inflammatory properties. Fraxinellone was found to inhibit LPS-induced nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production, and to reduce the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the mRNA and protein levels in a dose-dependent manner.
In Vitro

Cell Viability Assay Cell Line:A549 cells Concentration:0 μM, 10 μM, 30 μM, 100 μM Incubation Time:12 hours Result:Inhibited the percent of PD-L1 positive cells.
In Vivo

Animal Model:BALB/c nude miceDosage:30 and 100?mg/kg Administration:Oral gavage; 30 and 100?mg/kg; every three days; 30 daysResult:Significantly suppressed tumor growth.
Synonyms

Fraxinellone
Pathway

Metabolic Enzyme/Protease
Target

MMP
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

28808-62-0
Formula Weight

232.27
Molecular Formula

C14H16O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (430.51 mM)
SMILES

CC1=C2C(=O)OC(C2(CCC1)C)C3=COC=C3
Chemical Name

1(3H)-Isobenzofuranone, 3-(3-furanyl)-3a,4,5,6-tetrahydro-3a,7-dimethyl-, (3R-cis)- (9CI)