Tanomastat( BAY129566 | BAY 12-9566 )

Catalog No. M12711 CAS No. 179545-77-8

Tanomastat (BAY 129566) is a potent,orally available, non-peptidic inhibitor of MMP-2, MMP-3 and MMP-9 with 11, 143 and 301 nM, respectively.

Purity : >98% (HPLC)

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Biological Information

Product Name

Tanomastat
Note

Research use only, not for human use.
Brief Description

Tanomastat (BAY 129566) is a potent,orally available, non-peptidic inhibitor of MMP-2, MMP-3 and MMP-9 with 11, 143 and 301 nM, respectively.
Description

Tanomastat (BAY 129566) is a potent,orally available, non-peptidic inhibitor of MMP-2, MMP-3 and MMP-9 with 11, 143 and 301 nM, respectively; inhibits extracellular matrix degradation and potentially inhibiting angiogenesis, tumor growth and invasion, and metastasis both in vitro and in vivo.Ovarian Cancer Phase 3 Discontinued.
In Vitro

Tanomastat (BAY 12-9566) (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM), without affecting cell proliferation.Tanomastat (BAY 12-9566) (1-00 μM; 5 days) inhibits tubule formation completely at 15-100 μM.
In Vivo

Tanomastat (BAY 12-9566) (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth without causing any toxic effect, and inhibits the number and volume of lung metastases. Animal Model:Six- to eight-week-old female BALB/c nude mice (bearing MDA-MB-435 cells) Dosage:100 mg/kg Administration:p.o.; daily for a 7-week period Result:Inhibited local tumor regrowth by 58% without causing any toxic effect, and inhibited the number and volume of lung metastases by 57 and 88%, respectively.
Synonyms

BAY129566 | BAY 12-9566
Pathway

Metabolic Enzyme/Protease
Target

MMP
Recptor

MMP
Research Area

Cancer
Indication

Ovarian Cancer

Chemical Information

CAS Number

179545-77-8
Formula Weight

410.912
Molecular Formula

C23H19ClO3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)[C@@H](CSC1=CC=CC=C1)CC(C2=CC=C(C3=CC=C(Cl)C=C3)C=C2)=O
Chemical Name

(S)-4-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-oxo-2-((phenylthio)methyl)butanoic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Gatto C, et al. Clin Cancer Res. 1999 Nov;5(11):3603-7. 2. Rowinsky EK, et al. J Clin Oncol. 2000 Jan;18(1):178-86. 3. Leung D, et al. J Med Chem. 2000 Feb 10;43(3):305-41. 4. Moore MJ, et al. J Clin Oncol. 2003 Sep 1;21(17):3296-302.

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