Complanatoside A

Research use only, not for human use.

Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus.

Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus.

A simple and sensitive LC-MS/MS method is developed for the determination of complanatoside A in rat plasma over the range of 2.3–575 ng/mL. Complanatoside A is extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The lower limit of quantification is established at 2.3 ng/mL. Intra- and inter-day precisions (LLOQ, low-QC, med-QC and high-QC) are less than 7.9%, and accuracies are between 94.0 and 105.1%. Matrix effect is acceptable (97.9–103.0%) and extraction recovery is reproducible (88.5–94.4%). Complanatoside A is stable in the investigated conditions. The method is applied to the pharmacokinetics of complanatoside A in rats.

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GPCR/G Protein

S1P Receptor

Others

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146501-37-3

642.5

C27H30O18

>98% (HPLC)

In Vitro:?DMSO : ≥ 35.7 mg/mL (55.56 mM)

c1(c(c(=O)c2c(cc(cc2o1)O)O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)c1ccc(cc1)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO

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(-20℃)

With Ice Pack

≥ 2 years