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GLPG2938
CAS No. 2130996-00-6
GLPG2938( 1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea )
Catalog No. M23968 CAS No. 2130996-00-6
GLPG2938 is a potent and selective antagonist of S1P2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
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| 2MG | 93 | In Stock |
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| 5MG | 140 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 549 | In Stock |
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| 50MG | 775 | In Stock |
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| 100MG | 1070 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGLPG2938
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NoteResearch use only, not for human use.
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Brief DescriptionGLPG2938 is a potent and selective antagonist of S1P2.
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DescriptionGLPG2938 is a potent and selective antagonist of S1P2.
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In VitroGLPG2938 (0.5~5 μM; HPF cells) significantly prevents the S1P-mediated contraction at all tested concentrations.
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In VivoGLPG2938 (1~10 mg/kg; p.o.) displays a marked protective effect at all dosed tested, resulting in statistically significant reduction of the Ashcroft score.GLPG2938 shows good pharmacokinetics, with long half-life, low clearance, and good bioavailability in all species, especially in dogs. Animal Model:Male C57BL/6 mice Dosage:1~10 mg/kg Administration:P.o.Result:Displayed a marked protective effect at all dosed tested, resulting in statistically significant reduction of the Ashcroft score. ?
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Synonyms1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea
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PathwayGPCR/G Protein
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TargetS1P Receptor
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RecptorS1P2
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Research Area——
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Indication——
Chemical Information
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CAS Number2130996-00-6
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Formula Weight503.4
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Molecular FormulaC20H19F6N7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (198.65 mM)
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SMILESCCOc1cc(NC(NCc2nnc(-c3cn(C)nc3C(F)(F)F)c(C)c2)=O)cc(C(F)(F)F)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis[J]. Journal of Medicinal Chemistry, 2021, 64(9):6037-6058.
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