Anwuligan

Research use only, not for human use.

Anwuligan is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.

Macelignan is a lignan which can be found in the nutmeg. Macelignan acts as an NSAID with antioxidant, free radical scavenging, and neuroprotective activities.

Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm2, reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells.Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells. TCell Viability Assay Cell Line:Hacat cells Concentration:1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM Incubation Time:72 hours Result:Induced cell death by UVB irradiation at 30 mJ/cm2 from 10 μM.Western Blot Analysis Cell Line:Hacat cellsConcentration:0.1 μM; 0.5 μM;1 μM Incubation Time:24 hours Result:Reduced UVB-induced COX-2 expression in cells.

Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits?in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ-db/db?mice. Animal Model:Male C57BL/KsJ-db/db?mice Dosage:15 mg/kg Administration:Oral administration; 15 mg/kg; every day for three weeksResult:Significantly reduced the blood glucose levels in mice.

Macelignan

Endocrinology/Hormones

Estrogen Receptor/ERR

Others

Neurological Disease

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107534-93-0

328.41

C20H24O4

>98% (HPLC)

DMSO : ≥ 30 mg/mL; 91.35 mM

c1(c(cc(cc1)C[C@@H]([C@@H](Cc1cc2OCOc2cc1)C)C)OC)O

Phenol, 4-((2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl)-2-methoxy-

(-20℃)

With Ice Pack

≥ 2 years