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G36
CAS No. 1392487-51-2
G36( —— )
Catalog No. M33854 CAS No. 1392487-51-2
G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
|
| 5MG | 76 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 240 | In Stock |
|
| 50MG | 397 | In Stock |
|
| 100MG | 588 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1256 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameG36
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NoteResearch use only, not for human use.
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Brief DescriptionG36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively).
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DescriptionG-36 is a cell permeable non-steroidal antagonist of G-protein-coupled estrogen receptor (GPER/GPR30) which selectively inhibits estrogen-mediated activation of PI3K by GPER, but not by ERα. G-36 also inhibits estrogen-mediated calcium mobilization (IC50=112 nM).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorEstrogen Receptor/ERR
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Research Area——
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Indication——
Chemical Information
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CAS Number1392487-51-2
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Formula Weight412.32
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Molecular FormulaC22H22BrNO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (121.27 mM; Ultrasonic (<80°C)
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SMILES[H][C@]12CC=C[C@@]1([H])c1cc(ccc1N[C@H]2c1cc2OCOc2cc1Br)C(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dennis MK, Field AS, Burai R, Ramesh C, Petrie WK, Bologa CG, Oprea TI, Yamaguchi Y, Hayashi S, Sklar LA, Hathaway HJ, Arterburn JB, Prossnitz ER. Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Bioc?
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