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A-674563 HCl
CAS No. ——
A-674563 HCl ( —— )
Catalog No. M17709 CAS No. ——
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 138 | Get Quote |
|
| 10MG | 193 | Get Quote |
|
| 25MG | 348 | Get Quote |
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| 50MG | 520 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameA-674563 HCl
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NoteResearch use only, not for human use.
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Brief DescriptionA-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) .
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DescriptionA-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1). It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorAkt1|CDK2|PKA
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight394.9
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Molecular FormulaC22H23ClN4O
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.Cc1[nH]nc2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Luo Y, Shoemaker A R, Liu X, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.[J]. Molecular Cancer Therapeutics, 2005, 4(6):977.
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