A-674563 HCl ( —— )

Catalog No. M17709 CAS No. ——

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) .

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

A-674563 HCl
Note

Research use only, not for human use.
Brief Description

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) .
Description

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1). It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families.
In Vitro

——
In Vivo

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Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

Akt1|CDK2|PKA
Research Area

——
Indication

——

Chemical Information

CAS Number

——
Formula Weight

394.9
Molecular Formula

C22H23ClN4O
Purity

>98% (HPLC)
Solubility

——
SMILES

Cl.Cc1[nH]nc2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Luo Y, Shoemaker A R, Liu X, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.[J]. Molecular Cancer Therapeutics, 2005, 4(6):977.

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