MN-64

Research use only, not for human use.

MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.

MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system. Tankyrases are ADP-ribosyltransferases that play key roles in various cellular pathways, including the regulation of cell proliferation, and thus, they are promising drug targets for the treatment of cancer.

MN-64 is a potent tankyrase 1 inhibitor, with IC50s of 6 nM, 72 nM, 19.1 μM, 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively. MN-64 effectively inhibits Wnt/β-catenin at 1 μM, and blocks STF luciferase activity at 200 nM.

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MN-64 | MN 64 | MN64

Neuroscience

Gamma-secretase

Tankyrase

Cancer

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92831-11-3

264.32

C18H16O2

>98% (HPLC)

DMSO : 100 mg/mL. 378.33 mM;

CC(C)c1ccc(cc1)c1cc(=O)c2ccccc2o1

2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one

(-20℃)

With Ice Pack

≥ 2 years