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GSK269962A

CAS No. 850664-21-0

GSK269962A( GSK 269962 )

Catalog No. M17614 CAS No. 850664-21-0

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 103 In Stock
5MG 78 In Stock
10MG 117 In Stock
25MG 226 In Stock
50MG 368 In Stock
100MG 538 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GSK269962A
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
  • Description
    GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague-Dawley rats (350-400g)Dosage:0.3, 1, and 3 mg/kg Administration:Oral gavage; 12 hours Result:Induced a dose-dependent reduction in blood pressure.
  • Synonyms
    GSK 269962
  • Pathway
    Angiogenesis
  • Target
    VEGFR
  • Recptor
    MSK1| ROCK1| ROCK2| RSK1
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    850664-21-0
  • Formula Weight
    570.61
  • Molecular Formula
    C29H30N8O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 30 mg/mL; 52.58 mM
  • SMILES
    CCn1c2cc(ncc2nc1c1nonc1N)Oc1cccc(c1)NC(=O)c1ccc(cc1)OCCN1CCOCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. Epub 2006 Oct 3.
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