Roquinimex( FCF89 | FCF89 | LS 2616 | Linomide. US brand name: Linomide )

Catalog No. M17607 CAS No. 84088-42-6

COA

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Product Name

Roquinimex
Note

Research use only, not for human use.
Brief Description

Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.
Description

Roquinimex, also known as LS 2616 and FCF89 (brande name: Linomide), is a quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages.
In Vitro

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In Vivo

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Synonyms

FCF89 | FCF89 | LS 2616 | Linomide. US brand name: Linomide
Pathway

Wnt/Notch/Hedgehog
Target

Wnt/beta/catenin
Recptor

Others
Research Area

Inflammation/Immunology
Indication

——

CAS Number

84088-42-6
Formula Weight

308.34
Molecular Formula

C18H16N2O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 83.3 mg/mL; 270.17 mM
SMILES

CN(c1ccccc1)C(=O)C3=C(O)c2ccccc2N(C)C3=O
Chemical Name

4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

1.Liu Q,etal. Roquinimex inhibits dextran sodium sulfate-induced murine colitis.Inflamm Res. 2003 Feb;52(2):64-8.

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