RHPS4( —— )

Catalog No. M17501 CAS No. 390362-78-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

RHPS4
Note

Research use only, not for human use.
Brief Description

RHPS4 is a potent inhibitor of Telomerase at submicromolar.
Description

RHPS4 is a potent inhibitor of Telomerase at submicromolar.
In Vitro

Cell Proliferation Assay Cell Line:MCF-7, MCF-7 vector control, and MCF-7 c81 cells.Concentration:0, 0.2, 0.5, or 1 μM.Incubation Time:7 days.Result:Inhibited cell proliferation.
In Vivo

Animal Model:CD-1 male nude (nu/nu) mice, 6–8 weeks old and weighing 22-24 g (H460, CG5 and HT29, PC3 and M14 cancer models).Dosage:15 mg/kg.Administration:IV, daily for 15 consecutive days.Result:Active as a single agent on all the tumors analyzed. CG5 breast xenografts resulted in the most sensitive tumor.
Synonyms

——
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

Telomerase
Research Area

Cancer
Indication

——

CAS Number

390362-78-4
Formula Weight

458.48
Molecular Formula

C22H17F2N2·CH3O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 1 mg/mL (2.18 mM)
SMILES

CC1=CC2=C3C(=C1)C4=C(C=CC(=C4)F)[N+](=C3C5=C(N2C)C=CC(=C5)F)C.COS(=O)(=O)[O-]
Chemical Name

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