LY2090314( LY2090314 | LY-2090314 | LY 2090314. )

Catalog No. M15255 CAS No. 603288-22-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

LY2090314
Note

Research use only, not for human use.
Brief Description

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM.
Description

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. Phase 2.
In Vitro

——
In Vivo

——
Synonyms

LY2090314 | LY-2090314 | LY 2090314.
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3α| GSK-3β
Research Area

Cancer
Indication

——

CAS Number

603288-22-8
Formula Weight

512.53
Molecular Formula

C28H25FN6O3
Purity

>98% (HPLC)
Solubility

Ethanol: 2 mg/mL warmed (3.9 mM); DMSO: 100 mg/mL (195.11 mM)
SMILES

O=C(C(C1=CN2C3=C1C=C(F)C=C3CN(C(N4CCCCC4)=O)CC2)=C5C6=CN=C7C=CC=CN76)NC5=O
Chemical Name

3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione

1. Brail LH, et al. J Clin Oncol, 2011, 29, abstr 3030.

Calculator

molnova catalog