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I-CBP112 hydrochloride
CAS No. 2147701-33-3
I-CBP112 hydrochloride( —— )
Catalog No. M17434 CAS No. 2147701-33-3
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 447 | In Stock |
|
| 2MG | 141 | In Stock |
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| 5MG | 237 | In Stock |
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| 10MG | 447 | In Stock |
|
| 25MG | 734 | In Stock |
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| 50MG | 1004 | In Stock |
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| 100MG | 1358 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameI-CBP112 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionI-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains.
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DescriptionI-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorCBP/p300, Leukemia cell| CBP/p300, Prostate cancer cell
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Research Area——
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Indication——
Chemical Information
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CAS Number2147701-33-3
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Formula Weight505
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Molecular FormulaC27H36N2O5HCl
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Purity>98% (HPLC)
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Solubility——
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SMILESCCC(=O)N1CCOC2=C(C1)C=C(C=C2OC[C@H]3CCCN(C3)C)C4=CC(=C(C=C4)OC)OC.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zucconi BE, et al. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain LigandI-CBP112. Biochemistry. 2016 Jul 12;55(27):3727-34.
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