Tyrphostin AG 879( Val-boroPro (mesylate) | PT100 (mesylate) )

Catalog No. M17320 CAS No. 148741-30-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Tyrphostin AG 879
Note

Research use only, not for human use.
Brief Description

Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
Description

AG-879 is a tyrphostin compound that inhibits nerve growth factor-dependent TrkA tyrosine phosphorylation in PC-12 cells, HER2-ErbB2 kinase in several breast and ovarian cancer cell lines, and the VEGF receptor FLK1. It decreases cellular proliferation in human muscular sarcoma cell lines.
In Vitro

Cell Proliferation Assay Cell Line:HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells Concentration:0.5 μM, 5 μM, 20 μM and 50 μM Incubation Time:48 hours Result:Significantly and dose dependently decreased cell proliferation in all the cell lines.Apoptosis Analysis Cell Line:HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells Concentration:0.5 μM, 5 μM, 20 μM and 50 μM Incubation Time:48 hours Result:Induced a dose-dependent increase in apoptosis.
In Vivo

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Synonyms

Val-boroPro (mesylate) | PT100 (mesylate)
Pathway

Angiogenesis
Target

ALK
Recptor

EGFR| HER2-Neu| PDGFR| Trk
Research Area

Cancer
Indication

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CAS Number

148741-30-4
Formula Weight

316.46
Molecular Formula

C18H24N2OS
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 30 mg/mL. 94.80 mM
SMILES

Oc1c(C(C)(C)C)cc(/C=C(\C#N)/C(=S)N)cc1C(C)(C)C
Chemical Name

2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-

1. Zhou Y, et al. Cancer Res, 2005, 65(13), 5848-5856.

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