CEP-28122 mesylate( —— )

Catalog No. M16991 CAS No. ——

COA

Datasheet

HNMR

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Product Name

CEP-28122 mesylate
Note

Research use only, not for human use.
Brief Description

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
Description

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM; exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM; shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).
In Vitro

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In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

ALK
Recptor

ALK
Research Area

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Indication

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CAS Number

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Formula Weight

635.1746
Molecular Formula

C29H39ClN6O6S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 6.4 mg/mL; DMSO < 9.2 mg/mL
SMILES

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Chemical Name

Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-, methanesulfonate (1:1)

1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9. 2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

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