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CEP-28122
CAS No. 1022958-60-6
CEP-28122( CEP28122 | CEP 28122 | CEP28122 )
Catalog No. M10107 CAS No. 1022958-60-6
A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 68 | In Stock |
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| 5MG | 122 | In Stock |
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| 10MG | 197 | In Stock |
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| 25MG | 356 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCEP-28122
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
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DescriptionA highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM; exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM; shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).
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In Vitro——
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In Vivo——
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SynonymsCEP28122 | CEP 28122 | CEP28122
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PathwayAngiogenesis
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TargetALK
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RecptorALK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1022958-60-6
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Formula Weight539.0689
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Molecular FormulaC28H35ClN6O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C([C@H]1[C@](C2)([H])C=C[C@]2([H])[C@H]1NC3=NC(NC4=CC=C5C(CC[C@@H](N6CCOCC6)CC5)=C4OC)=NC=C3Cl)N
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Chemical NameBicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9.
2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.
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