CEP-28122( CEP28122 | CEP 28122 | CEP28122 )

Catalog No. M10107 CAS No. 1022958-60-6

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Product Name

CEP-28122
Note

Research use only, not for human use.
Brief Description

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
Description

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM; exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM; shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).
In Vitro

——
In Vivo

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Synonyms

CEP28122 | CEP 28122 | CEP28122
Pathway

Angiogenesis
Target

ALK
Recptor

ALK
Research Area

Cancer
Indication

——

CAS Number

1022958-60-6
Formula Weight

539.0689
Molecular Formula

C28H35ClN6O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C([C@H]1[C@](C2)([H])C=C[C@]2([H])[C@H]1NC3=NC(NC4=CC=C5C(CC[C@@H](N6CCOCC6)CC5)=C4OC)=NC=C3Cl)N
Chemical Name

Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-

1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9. 2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

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