Cart
sales@molnova.com
LDN193189 hydrochloride
CAS No. 1062368-62-0
LDN193189 hydrochloride( LDN 193189 hydrochloride | LDN-193189 hydrochloride )
Catalog No. M10278 CAS No. 1062368-62-0
LDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
|
| 5MG | 65 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 146 | In Stock |
|
| 50MG | 254 | In Stock |
|
| 100MG | 381 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLDN193189 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionLDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM.
-
DescriptionLDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM, displays >200-fold selectivity for BMP signaling over TGF-β signaling (IC50>1,000 nM); efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7; also blocks the transcriptional activity induced by either constitutively active ALK2 R206H or ALK2 Q207D mutant proteins, affects BMP-induced osteoblast differentiation, attenuates ectopic ossification in vivo.
-
In Vitro——
-
In Vivo——
-
SynonymsLDN 193189 hydrochloride | LDN-193189 hydrochloride
-
PathwayAngiogenesis
-
TargetALK
-
RecptorALK2|ALK3
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1062368-62-0
-
Formula Weight552.3261
-
Molecular FormulaC25H26Cl4N6
-
Purity>98% (HPLC)
-
SolubilityH2O: 20 mg/mL
-
SMILES[H]Cl.C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16
-
Chemical NameQuinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-, hydrochloride (1:1)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Yu PB, et al. Nat Med. 2008 Dec;14(12):1363-9.
2. Cuny GD, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4388-92.
3. Cannon JE, et al. Br J Pharmacol. 2010 Sep;161(1):140-9.
4. Steinbicker AU, et al. Blood. 2011 May 5;117(18):4915-23.
molnova catalog
related products
-
5-phenylthieno[2,3-d...
5-phenylthieno[2,3-d]pyrimidin-4-amine is a chemical compound.
-
Zotizalkib
Zotizalkib (TPX-0131) is an orally active and selective ALK inhibitor with antitumor activity for the study of non-small cell lung cancer.
-
LDN193189
LDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM.
