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AG 494
CAS No. 133550-35-3
AG 494( AG-494 | AG 494 | AG494 | Tyrphostin AG-494. )
Catalog No. M17249 CAS No. 133550-35-3
AG-494 is an inhibitor of epidermal growth factor receptor kinase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | In Stock |
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| 10MG | 82 | In Stock |
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| 25MG | 147 | In Stock |
|
| 50MG | 230 | In Stock |
|
| 100MG | 370 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAG 494
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NoteResearch use only, not for human use.
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Brief DescriptionAG-494 is an inhibitor of epidermal growth factor receptor kinase.
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DescriptionAG-494, also known as Tyrphostin AG-494, is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells
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In VitroIn DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis.AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H2O2-treated cells.AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.
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In Vivo——
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SynonymsAG-494 | AG 494 | AG494 | Tyrphostin AG-494.
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorEGFR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number133550-35-3
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Formula Weight280.28
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Molecular FormulaC16H12N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (356.79 mM)
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SMILESc1ccc(cc1)NC(=O)/C(=C/c1cc(c(cc1)O)O)/C#N
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Chemical Name2E-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gazit, A. et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. Journal of Medicinal Chemistry 32(10), 2344-2352 (1989).
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