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TLR7/8 agonist 1 dihydrochloride
CAS No. 1620278-72-9
TLR7/8 agonist 1 dihydrochloride( TLR7/8 agonist-5d )
Catalog No. M20254 CAS No. 1620278-72-9
TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 120 | In Stock |
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| 10MG | 192 | In Stock |
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| 25MG | 406 | In Stock |
|
| 50MG | 597 | In Stock |
|
| 100MG | 851 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTLR7/8 agonist 1 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionTLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
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DescriptionTLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.(In Vitro):TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens.
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In VitroTLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens.
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In Vivo——
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SynonymsTLR7/8 agonist-5d
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR7| TLR8
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Research Area——
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Indication——
Chemical Information
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CAS Number1620278-72-9
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Formula Weight432.39
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Molecular FormulaC22H27Cl2N5
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Purity>98% (HPLC)
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SolubilityDMSO: 70 mg/mL (161.89 mM)
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SMILESCl.Cl.CCCCc1nc2c(N)nc3ccccc3c2n1Cc1ccc(CN)cc1
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Chemical Name2-(4-(Aminomethyl)benzyl)-1-butyl-1H-imidazo[45-c]quinolin-4-amine dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shukla NM et al. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6384-6.
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