ARQ 621( ARQ621 | ARQ 621 | ARQ-621 )

Catalog No. M17142 CAS No. 1095253-39-6

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Product Name

ARQ 621
Note

Research use only, not for human use.
Brief Description

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
Description

ARQ-621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target. Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies.(In Vitro):Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target.
In Vitro

Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target.
In Vivo

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Synonyms

ARQ621 | ARQ 621 | ARQ-621
Pathway

Metabolic Enzyme/Protease
Target

BACE
Recptor

Eg5 mitotic motor protein
Research Area

Cancer
Indication

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CAS Number

1095253-39-6
Formula Weight

552.43
Molecular Formula

C28H24Cl2FN5O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 110 mg/mL (199.12 mM)
SMILES

NCCCN([C@H](CC#C)C1=NC2=C(C=CC(Cl)=C2)C(=O)N1NC1=CC=CC=C1)C(=O)C1=CC=CC(Cl)=C1F
Chemical Name

(R)-N-(3-aminopropyl)-3-chloro-N-(1-(7-chloro-4-oxo-3-(phenylamino)-3,4-dihydroquinazolin-2-yl)but-3-yn-1-yl)-2-fluorobenzamide

1. Rosen L, et al. Annual Meeting of ASCO: abstract 3076

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