Corynoxine

Research use only, not for human use.

Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines including N2a and SHSY-5Y cells.

Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines including N2a and SHSY-5Y cells.

Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner.Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction. Western Blot Analysis Cell Line:N2a and SH-SY5Y cells Concentration:6.25, 12.5, 25 μM Incubation Time:6, 12 hours Result:Induced autophagy in neuronal cell lines.

Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice.Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila.

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Metabolic Enzyme/Protease

BACE

Autophagy

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6877-32-3

384.47

C22H28N2O4

>98% (HPLC)

DMSO: 50 mg/mL;Ethanol: 50 mg/mL;Water: Insoluble

CC[C@@H]1CN2CC[C@]3([C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC)C(=O)Nc1ccccc31

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(-20℃)

With Ice Pack

≥ 2 years