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Corynoxine
CAS No. 6877-32-3
Corynoxine( —— )
Catalog No. M19889 CAS No. 6877-32-3
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines including N2a and SHSY-5Y cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 95 | In Stock |
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| 5MG | 86 | In Stock |
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| 10MG | 122 | In Stock |
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| 25MG | 204 | In Stock |
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| 50MG | 296 | In Stock |
|
| 100MG | 436 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCorynoxine
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NoteResearch use only, not for human use.
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Brief DescriptionCorynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines including N2a and SHSY-5Y cells.
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DescriptionCorynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines including N2a and SHSY-5Y cells.
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In VitroCorynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner.Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction. Western Blot Analysis Cell Line:N2a and SH-SY5Y cells Concentration:6.25, 12.5, 25 μM Incubation Time:6, 12 hours Result:Induced autophagy in neuronal cell lines.
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In VivoCorynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice.Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetBACE
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number6877-32-3
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Formula Weight384.47
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Molecular FormulaC22H28N2O4
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Purity>98% (HPLC)
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SolubilityDMSO: 50 mg/mL;Ethanol: 50 mg/mL;Water: Insoluble
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SMILESCC[C@@H]1CN2CC[C@]3([C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC)C(=O)Nc1ccccc31
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chen LL et al. Corynoxine a natural autophagy enhancer promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9(3):380-7.
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