VERU-111 analogue 13f( —— )

Catalog No. M17045 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

VERU-111 analogue 13f
Note

Research use only, not for human use.
Brief Description

VERU-111 analogue 13f is a novel potent colchicine binding site inhibitor (CBSI) in tubulin with potential anticancer activities.
Description

VERU-111 analogue 13f is a novel potent colchicine binding site inhibitor (CBSI) in tubulin with potential anticancer activities; inhibits cell viability of human melanoma cell lines (A375, M14, and RPMI7951) with IC50 of 1-3 nM; VERU-111 analogue 13f is significantly more potent than VERU-111, exhibits a strong inhibitory effect on tumor growth in vivo.
In Vitro

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In Vivo

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Synonyms

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Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

Microtubule/Tubulin
Research Area

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Indication

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CAS Number

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Formula Weight

373.368
Molecular Formula

C21H15N3O4
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

(2-(1H-indol-3-yl)-1H-imidazol-5-yl)(8-methoxybenzo[b][1,4]dioxin-6-yl)methanone

1. Wang Q, et al. J Med Chem. 2018 Aug 30. doi: 10.1021/acs.jmedchem.8b00827.

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