Tubulin inhibitor 24

Research use only, not for human use.

Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.

Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.

Tubulin inhibitor 24 (compound 1b) () shows high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 μM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively.Tubulin inhibitor 24 inhibites tubulin polymerization with an IC50 value of 2.1 μM.Tubulin inhibitor 24 (5, 10 nM) induces cell cycle arrest at the G2/M phase in a concentration-dependent manner.Tubulin inhibitor 24 (10, 20, 40 nM; 24 h) inhibits MCF-7 cancer cells migration in a dose-dependent manner.Tubulin inhibitor 24 (40 nM; 6 h) destabilizes microtubule by inhibiting tubulin polymerization and disturbing microtubule networks in B16-F10 cells. Cell Proliferation Assay Cell Line:Hela, MCF-7, A549, HCT-116, B16-F10 cells Concentration:0.00098, 0.0039, 0.016, 0.0625, 0.25, 1.0, 4.0, 16, 64 μM Incubation Time:48 hResult:Showed high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 μM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively.Cell Cycle Analysis Cell Line:MCF-7 cells Concentration:5, 10 nM Incubation Time:48 h Result:Cells were arrested at the G2/M phase in a concentration-dependent manner.

Tubulin inhibitor 24 (10, 20 mg/kg; i.p.; per day for 16 days) shows antitumor activity with no obvious toxicity. Animal Model:4-6 weeks, male C57/BL mice (B16e-10 tumor model)Dosage:10, 20 mg/kg (formulated in 5% DMSO, 40% PEG-300 and 55% saline)Administration: I.p.; per day, 16 days Result:Showed antitumor activity with no obvious toxicity.

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Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

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2415761-65-6

375.42

C22H21N3O3

>98% (HPLC)

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COC1=CC(=CC(OC)=C1OC)C1=CC=NC2=CC(=NN12)C1=CC=C(C)C=C1

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(-20℃)

With Ice Pack

≥ 2 years