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TAS-117 hydrochloride
CAS No. ——
TAS-117 hydrochloride( TAS117 )
Catalog No. M17013 CAS No. ——
TAS-117 is a potent, selective, allosteric inhibitor of Akt with IC50 of 4.8/1.6/44 for Akt1/2/3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTAS-117 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionTAS-117 is a potent, selective, allosteric inhibitor of Akt with IC50 of 4.8/1.6/44 for Akt1/2/3, respectively.
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DescriptionTAS-117 is a potent, selective, allosteric inhibitor of Akt with IC50 of 4.8/1.6/44 for Akt1/2/3, respectively; displays no or only minimal inhibitory activities against other protein and lipid kinases, including PI3K, PDK1, and mTOR at 1 uM; inhibits Akt kinase activity but not p-Akt; induces significant growth inhibition, associated with downregulation of p-Akt, selectively in MM cell lines with high baseline p-Akt; significantly inhibits human MM cell growth in murine xenograft models, orally active.Solid Tumors Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsTAS117
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight460.962
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Molecular FormulaC26H25ClN4O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameTrans-3-amino-1methyl-3-[4-(3-phenyl-5H- imidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl]-cyclobutanol hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mimura N, et al. Cancer Res. 2014 Aug 15;74(16):4458-69.
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