TAS-117 hydrochloride

CAS No. ——

TAS-117 hydrochloride( TAS117 )

Catalog No. M17013 CAS No. ——

TAS-117 is a potent, selective, allosteric inhibitor of Akt with IC50 of 4.8/1.6/44 for Akt1/2/3, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TAS-117 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    TAS-117 is a potent, selective, allosteric inhibitor of Akt with IC50 of 4.8/1.6/44 for Akt1/2/3, respectively.
  • Description
    TAS-117 is a potent, selective, allosteric inhibitor of Akt with IC50 of 4.8/1.6/44 for Akt1/2/3, respectively; displays no or only minimal inhibitory activities against other protein and lipid kinases, including PI3K, PDK1, and mTOR at 1 uM; inhibits Akt kinase activity but not p-Akt; induces significant growth inhibition, associated with downregulation of p-Akt, selectively in MM cell lines with high baseline p-Akt; significantly inhibits human MM cell growth in murine xenograft models, orally active.Solid Tumors Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TAS117
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    460.962
  • Molecular Formula
    C26H25ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Trans-3-amino-1methyl-3-[4-(3-phenyl-5H- imidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl]-cyclobutanol hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mimura N, et al. Cancer Res. 2014 Aug 15;74(16):4458-69.
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