TAS-117 hydrochloride( TAS117 )

Catalog No. M17013 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TAS-117 hydrochloride
Note

Research use only, not for human use.
Brief Description

TAS-117 is a potent, selective, allosteric inhibitor of Akt with IC50 of 4.8/1.6/44 for Akt1/2/3, respectively.
Description

TAS-117 is a potent, selective, allosteric inhibitor of Akt with IC50 of 4.8/1.6/44 for Akt1/2/3, respectively; displays no or only minimal inhibitory activities against other protein and lipid kinases, including PI3K, PDK1, and mTOR at 1 uM; inhibits Akt kinase activity but not p-Akt; induces significant growth inhibition, associated with downregulation of p-Akt, selectively in MM cell lines with high baseline p-Akt; significantly inhibits human MM cell growth in murine xenograft models, orally active.Solid Tumors Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

TAS117
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Akt
Recptor

Akt
Research Area

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Indication

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CAS Number

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Formula Weight

460.962
Molecular Formula

C26H25ClN4O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Trans-3-amino-1methyl-3-[4-(3-phenyl-5H- imidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl]-cyclobutanol hydrochloride

1. Mimura N, et al. Cancer Res. 2014 Aug 15;74(16):4458-69.

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