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CR6086
CAS No. ——
CR6086( CR 6086 | CR-6086 )
Catalog No. M16966 CAS No. ——
CR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCR6086
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NoteResearch use only, not for human use.
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Brief DescriptionCR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor).
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DescriptionCR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM; reduces key cytokine players of RA (IL-6 and VEGF expression in macrophages, IL-23 release from dendritic cells, IL-17 release from Th17 cells) in models of human immune cells in culture; significantly improves all features of arthritis: severity, histology, inflammation and pain in CIA models of RA in rats and mice; CR6086 is better than the selective COX-2 inhibitor rofecoxib and at least as effective as the JAK inhibitor tofacitinib.Rheumatoid Arthritis Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsCR 6086 | CR-6086
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorProstaglandin Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight494.49
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Molecular FormulaC26H26F3N2NaO3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameSodium (R)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Caselli G, et al. Arthritis Res Ther. 2018 Mar 1;20(1):39.
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