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DS-6930b
CAS No. ——
DS-6930b( DS-6930 calcium salt | DS6930b )
Catalog No. M16962 CAS No. ——
DS-6930b (DS-6930 calcium salt) is the calcium salt of DS-6930, which is a novel potent, selective PPARγ agonist with EC50 of 41 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameDS-6930b
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NoteResearch use only, not for human use.
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Brief DescriptionDS-6930b (DS-6930 calcium salt) is the calcium salt of DS-6930, which is a novel potent, selective PPARγ agonist with EC50 of 41 nM.
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DescriptionDS-6930b (DS-6930 calcium salt) is the calcium salt of DS-6930, which is a novel potent, selective PPARγ agonist with EC50 of 41 nM, Emax-68%; significantly recruits several cofactors, such as RIP140 and PGC1, in cofactor recruitment assays; demonstrateshigh PPARγ agonist potency with robust plasma glucose reduction, maintains diminished PPARγ-related adverse effects upon toxicological evaluation in vivo, and demonstrated no hepatotoxicity.Diabetes Discontinued.
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In Vitro——
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In Vivo——
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SynonymsDS-6930 calcium salt | DS6930b
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PathwayMetabolic Enzyme/Protease
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TargetPPAR
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RecptorPPAR
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight——
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3-((6-((3,5-dimethylpyridin-2-yl)oxy)-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzoic acid 1/2 calcium
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shinozuka T, et al. Bioorg Med Chem. 2018 Oct 1;26(18):5099-5117.
2. Shinozuka T, et al. Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098.
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