DS-6930b( DS-6930 calcium salt | DS6930b )

Catalog No. M16962 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DS-6930b
Note

Research use only, not for human use.
Brief Description

DS-6930b (DS-6930 calcium salt) is the calcium salt of DS-6930, which is a novel potent, selective PPARγ agonist with EC50 of 41 nM.
Description

DS-6930b (DS-6930 calcium salt) is the calcium salt of DS-6930, which is a novel potent, selective PPARγ agonist with EC50 of 41 nM, Emax-68%; significantly recruits several cofactors, such as RIP140 and PGC1, in cofactor recruitment assays; demonstrateshigh PPARγ agonist potency with robust plasma glucose reduction, maintains diminished PPARγ-related adverse effects upon toxicological evaluation in vivo, and demonstrated no hepatotoxicity.Diabetes Discontinued.
In Vitro

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In Vivo

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Synonyms

DS-6930 calcium salt | DS6930b
Pathway

Metabolic Enzyme/Protease
Target

PPAR
Recptor

PPAR
Research Area

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Indication

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CAS Number

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Formula Weight

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Molecular Formula

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Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

3-((6-((3,5-dimethylpyridin-2-yl)oxy)-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzoic acid 1/2 calcium

1. Shinozuka T, et al. Bioorg Med Chem. 2018 Oct 1;26(18):5099-5117. 2. Shinozuka T, et al. Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098.

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