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FV-100

CAS No. 956483-03-7

FV-100( Valnivudine | FV100 | CF-1743 )

Catalog No. M16827 CAS No. 956483-03-7

FV-100 (Valnivudine, CF-1743) is a potent, selective, bicyclic nucleoside analogue inhibitor of varicella zoster virus (VZV) with EC50 of subnanomolar range in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FV-100
  • Note
    Research use only, not for human use.
  • Brief Description
    FV-100 (Valnivudine, CF-1743) is a potent, selective, bicyclic nucleoside analogue inhibitor of varicella zoster virus (VZV) with EC50 of subnanomolar range in vitro.
  • Description
    FV-100 (Valnivudine, CF-1743) is a potent, selective, bicyclic nucleoside analogue inhibitor of varicella zoster virus (VZV) with EC50 of subnanomolar range in vitro.HSV Infection Phase 3 Clinical.
  • In Vitro
    FV-100 is intensely fluorescent when illuminated by wavelengths of 340-380 nm.FV-100 (1 h) produces a different distribution in HeLa cells.
  • In Vivo
    FV-100 (50-500 mg/kg; p.o.) does not induce biologically relevant respiratory changes or any apparent neuropharmacological effects in rats.
  • Synonyms
    Valnivudine | FV100 | CF-1743
  • Pathway
    Microbiology/Virology
  • Target
    HSV
  • Recptor
    HSV
  • Research Area
    Infection
  • Indication
    HSV Infection

Chemical Information

  • CAS Number
    956483-03-7
  • Formula Weight
    548.077
  • Molecular Formula
    C28H38ClN3O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (187.25 mM)
  • SMILES
    CCCCCC1=CC=C(C=C1)C2=CC3=CN(C(=O)N=C3O2)C4CC(C(O4)COC(=O)C(C(C)C)N)O.Cl
  • Chemical Name
    ((2R,3S,5R)-3-hydroxy-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)tetrahydrofuran-2-yl)methyl (S)-3-amino-4-methylpentanoate hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. McGuigan C, et al. J Antimicrob Chemother. 2007 Dec;60(6):1316-30. 2. Pentikis HS, et al. Antimicrob Agents Chemother. 2011 Jun;55(6):2847-54. 3. Migliore M. Antivir Chem Chemother. 2010 Jan 5;20(3):107-15. 4. Tyring SK, et al. J Med Virol. 2017 Jul;89(7):1255-1264.
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