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Fluvastatin sodium salt
CAS No. 93957-55-2
Fluvastatin sodium salt( Canef | Fluindostatin | Lescol XL | Lipaxan | Vastin | XU-62-320 | XU62320 )
Catalog No. M16723 CAS No. 93957-55-2
Fluvastatin sodium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 60 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 42 | In Stock |
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| 50MG | 59 | In Stock |
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| 100MG | 82 | In Stock |
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| 200MG | 114 | In Stock |
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| 500MG | 184 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFluvastatin sodium salt
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NoteResearch use only, not for human use.
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Brief DescriptionFluvastatin sodium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR).
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DescriptionFluvastatin sodium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), used to treat hypercholesterolemia and to prevent cardiovascular disease.(In Vitro):Fluvastatin sodium (XU 62320) is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin (XU 62320), HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin (XU 62320) is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
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In VitroFluvastatin sodium (XU 62320) is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin (XU 62320), HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin (XU 62320) is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
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In Vivo——
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SynonymsCanef | Fluindostatin | Lescol XL | Lipaxan | Vastin | XU-62-320 | XU62320
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PathwayMetabolic Enzyme/Protease
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TargetHMGCR
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RecptorHMG-CoA reductase
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number93957-55-2
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Formula Weight433.45
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Molecular FormulaC24H25FNNaO4
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Purity>98% (HPLC)
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SolubilityWater: 1 mg/mL (2.3 mM); DMSO: 87 mg/mL (200.71 mM)
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SMILESO=C([O-])C[C@@H](O)C[C@@H](O)/C=C/C(N1C(C)C)=C(C2=CC=C(F)C=C2)C3=C1C=CC=C3.[Na+]
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Chemical Namesodium (3S,5R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dansette PM, et al. Exp Toxicol Pathol, 2000, 52(2), 145-148.
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