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Apomine
CAS No. 126411-13-0
Apomine( APB-231-A-2 | SK&F-99085 | SR-45023A | SR-9223i | APB-231-A2 )
Catalog No. M27850 CAS No. 126411-13-0
Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase and stimulates low-density lipoprotein receptor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 196 | In Stock |
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| 5MG | 159 | In Stock |
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| 10MG | 226 | In Stock |
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| 25MG | 378 | In Stock |
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| 50MG | 517 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameApomine
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NoteResearch use only, not for human use.
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Brief DescriptionApomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase and stimulates low-density lipoprotein receptor activity.
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DescriptionApomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase and stimulates low-density lipoprotein receptor activity. Apomine enhances the antitumor effect of lovastatin on myeloma cells by downregulating 3-hydroxy-3-methylglutaryl-CoA reductase.
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In Vitro——
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In Vivo——
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SynonymsAPB-231-A-2 | SK&F-99085 | SR-45023A | SR-9223i | APB-231-A2
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PathwayMetabolic Enzyme/Protease
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TargetHMGCR
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RecptorParasite
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Research Area——
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Indication——
Chemical Information
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CAS Number126411-13-0
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Formula Weight562.665
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Molecular FormulaC28H52O7P2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)OP(=O)(OC(C)C)C(Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)P(=O)(OC(C)C)OC(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Paul R Gilson, et al. Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity. J Med Chem. 2017 Feb 9;60(3):1171-1188.
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