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Setmelanotide

CAS No. 920014-72-8

Setmelanotide( RM-493 | BIM-22493 | IRC-022493 )

Catalog No. M16601 CAS No. 920014-72-8

Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 428 In Stock
5MG 230 In Stock
10MG 359 In Stock
25MG 649 In Stock
50MG 1023 In Stock
100MG 1395 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Setmelanotide
  • Note
    Research use only, not for human use.
  • Brief Description
    Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively.
  • Description
    Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively; exhibits weak activity at MC5R (EC50>1 uM) and inactive at the mouse MC2R (EC50>10 uM); acutely improves glucose homeostasis, causes weight loss and improves hyperinsulinemia and fatty liver in diet induced obese mice.Obesity Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RM-493 | BIM-22493 | IRC-022493
  • Pathway
    GPCR/G Protein
  • Target
    Melanocortin Receptor
  • Recptor
    Melanocortin Receptor
  • Research Area
    Metabolic Disease
  • Indication
    Obesity

Chemical Information

  • CAS Number
    920014-72-8
  • Formula Weight
    1117.309
  • Molecular Formula
    C49H68N18O9S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CCCN=C(N)N)NC(=O)C)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5
  • Chemical Name
    L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kumar KG, et al. Peptides. 2009 Oct;30(10):1892-900. 2. Chen KY, et al. J Clin Endocrinol Metab. 2015 Apr;100(4):1639-45. 3. Bischof JM, et al. Br J Pharmacol. 2016 Sep;173(17):2614-21.
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