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Setmelanotide
CAS No. 920014-72-8
Setmelanotide( RM-493 | BIM-22493 | IRC-022493 )
Catalog No. M16601 CAS No. 920014-72-8
Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 230 | In Stock |
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| 10MG | 358 | In Stock |
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| 25MG | 647 | In Stock |
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| 50MG | 1048 | In Stock |
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| 100MG | 1427 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSetmelanotide
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NoteResearch use only, not for human use.
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Brief DescriptionSetmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively.
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DescriptionSetmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively; exhibits weak activity at MC5R (EC50>1 uM) and inactive at the mouse MC2R (EC50>10 uM); acutely improves glucose homeostasis, causes weight loss and improves hyperinsulinemia and fatty liver in diet induced obese mice.Obesity Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsRM-493 | BIM-22493 | IRC-022493
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PathwayGPCR/G Protein
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TargetMelanocortin Receptor
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RecptorMelanocortin Receptor
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Research AreaMetabolic Disease
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IndicationObesity
Chemical Information
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CAS Number920014-72-8
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Formula Weight1117.309
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Molecular FormulaC49H68N18O9S2
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CCCN=C(N)N)NC(=O)C)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5
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Chemical NameL-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kumar KG, et al. Peptides. 2009 Oct;30(10):1892-900.
2. Chen KY, et al. J Clin Endocrinol Metab. 2015 Apr;100(4):1639-45.
3. Bischof JM, et al. Br J Pharmacol. 2016 Sep;173(17):2614-21.
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