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MCL 0020
CAS No. 475498-26-1
MCL 0020( —— )
Catalog No. M22356 CAS No. 475498-26-1
Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 283 | In Stock |
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| 10MG | 392 | In Stock |
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| 25MG | 604 | In Stock |
|
| 50MG | 809 | In Stock |
|
| 100MG | 1070 | In Stock |
|
| 200MG | 1451 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMCL 0020
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NoteResearch use only, not for human use.
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Brief DescriptionPotent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats.
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DescriptionPotent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
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In VitroMCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63.
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In VivoMCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice.MCL0020 significantly reverses stress-induced anorexia in rats.
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Synonyms——
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PathwayGPCR/G Protein
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TargetMelanocortin Receptor
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Recptormelanocortin-4 receptor (MC4R)
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Research Area——
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Indication——
Chemical Information
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CAS Number475498-26-1
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Formula Weight609.73
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Molecular FormulaC34H39N7O4
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Purity>98% (HPLC)
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Solubility25% ethanol / water:2 mg/mL
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SMILESCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID:
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